Exploring the Nattokinase enzyme that could reshape how we think about blood clot prevention, lipid health, and inflammation.
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What is Nattokinase?
Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans. While natto’s strong flavor and sticky texture may be polarizing, its health benefits are drawing attention in both scientific and metabolic health communities. Dr. Ben Bikman introduces nattokinase as a potentially powerful natural compound that mimics the effects of fibrinolytic drugs—without the associated bleeding risks.
Its primary benefit is its ability to break down fibrin, a key protein involved in blood clot formation. Nattokinase activates plasminogen, which the body normally uses to dissolve clots, allowing nattokinase to:
- Reduce blood viscosity
- Improve circulation
- Mimic pharmaceutical anti-clotting mechanisms naturally
Arterial Health and Cholesterol Markers
In a 2022 human clinical trial highlighted by Ben, nattokinase supplementation resulted in measurable improvements in arterial health. Over 36 weeks, participants taking nattokinase experienced:
- Reduced arterial plaque volume and thickness
- Improved triglyceride levels
- Slight increase in HDL (the so-called “good” cholesterol)
- Better results than statins in several key cardiovascular metrics
Dr. Bikman notes that while LDL cholesterol often takes center stage in heart health discussions, oxidized LDL is the more dangerous culprit. Nattokinase appears to reduce this oxidized form, possibly lowering the inflammatory stress on artery walls.
Metabolic Implications: Fat and Insulin
Beyond cardiovascular health, nattokinase may play a role in supporting healthy fat metabolism and insulin sensitivity. Animal studies have shown that nattokinase can activate two major fat-regulating enzymes:
- Lipoprotein Lipase (LPL) – helps clear fats from the blood
- Hormone-Sensitive Lipase (HSL) – aids in breaking down stored fat
Additionally, there’s early evidence suggesting nattokinase could improve insulin sensitivity. While human trials are still limited, these findings open the door for further research into nattokinase as a metabolic aid, especially for people struggling with insulin resistance or stubborn fat loss.
Caution and Bioavailability
For those who want to try nattokinase, Ben recommends:
- Looking for third-party tested supplements
- Starting with modest dosages
- Prioritizing whole food natto when possible
Takeaway
Nattokinase may offer a compelling, natural approach to supporting cardiovascular and metabolic health. Its fibrin-dissolving effects, influence on lipid markers, and potential metabolic benefits make it an exciting area of study—but not a magic bullet. Like most interventions, it’s most powerful when paired with good nutrition, resistance training, and metabolic awareness.
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